Explore the Potential with AI-Driven Innovation
This comprehensive focused library is produced on demand with state-of-the-art virtual screening and parameter assessment technology driven by Receptor.AI drug discovery platform. This approach outperforms traditional methods and provides higher-quality compounds with superior activity, selectivity and safety.
We carefully select specific compounds from a vast collection of over 60 billion molecules in virtual chemical space. Our partner Reaxense helps in synthesizing and delivering these compounds.
Contained in the library are leading modulators, each labelled with 38 ADME-Tox and 32 physicochemical and drug-likeness qualities. In addition, each compound is illustrated with its optimal docking poses, affinity scores, and activity scores, giving a complete picture.
We use our state-of-the-art dedicated workflow for designing focused libraries.
Fig. 1. The sreening workflow of Receptor.AI
Our strategy employs molecular simulations to explore an extensive range of proteins, capturing their dynamics both individually and within complexes with other proteins. Through ensemble virtual screening, we address proteins' conformational mobility, uncovering key binding sites at both functional regions and remote allosteric locations. This comprehensive investigation ensures a thorough assessment of all potential mechanisms of action, with the goal of discovering innovative therapeutic targets and lead molecules across across diverse biological functions.
Several key aspects differentiate our library:
partner
Reaxense
upacc
Q9BZE0
UPID:
GLIS2_HUMAN
Alternative names:
GLI-similar 2; Neuronal Krueppel-like protein
Alternative UPACC:
Q9BZE0; B3KX84
Background:
Zinc finger protein GLIS2, also known as GLI-similar 2 or Neuronal Krueppel-like protein, plays a pivotal role in cellular processes. It can function as both a transcriptional repressor and activator, influencing the Hedgehog signaling pathway and the Wnt signaling pathway. Its activity is crucial for maintaining the differentiated epithelial phenotype in renal cells and may be involved in neuron differentiation.
Therapeutic significance:
GLIS2's involvement in Nephronophthisis 7, a severe renal disorder, underscores its therapeutic significance. Understanding the role of Zinc finger protein GLIS2 could open doors to potential therapeutic strategies for this and possibly other related diseases.