Explore the Potential with AI-Driven Innovation
This comprehensive focused library is produced on demand with state-of-the-art virtual screening and parameter assessment technology driven by Receptor.AI drug discovery platform. This approach outperforms traditional methods and provides higher-quality compounds with superior activity, selectivity and safety.
Our selection of compounds is from a large virtual library of over 60 billion molecules. The production and distribution of these compounds are managed by our partner Reaxense.
The library includes a list of the most effective modulators, each annotated with 38 ADME-Tox and 32 physicochemical and drug-likeness parameters. Furthermore, each compound is shown with its optimal docking poses, affinity scores, and activity scores, offering a detailed summary.
We use our state-of-the-art dedicated workflow for designing focused libraries.
Fig. 1. The sreening workflow of Receptor.AI
Our strategy employs molecular simulations to explore an extensive range of proteins, capturing their dynamics both individually and within complexes with other proteins. Through ensemble virtual screening, we address proteins' conformational mobility, uncovering key binding sites at both functional regions and remote allosteric locations. This comprehensive investigation ensures a thorough assessment of all potential mechanisms of action, with the goal of discovering innovative therapeutic targets and lead molecules across across diverse biological functions.
Our library distinguishes itself through several key aspects:
partner
Reaxense
upacc
Q9BZL1
UPID:
UBL5_HUMAN
Alternative names:
-
Alternative UPACC:
Q9BZL1; Q2NL89
Background:
Ubiquitin-like protein 5 (UBL5), also known as ISG15, plays a crucial role in cellular processes through its involvement in the ubiquitin-proteasome pathway. This pathway is essential for protein degradation, signaling, and cell cycle control. UBL5 is characterized by its ability to be conjugated to target proteins, a process that alters their function, location, or stability, thereby regulating various cellular pathways.
Therapeutic significance:
Understanding the role of Ubiquitin-like protein 5 could open doors to potential therapeutic strategies. Its pivotal role in the ubiquitin-proteasome pathway, a critical system for cellular homeostasis, makes it a potential target for drug discovery efforts aimed at treating diseases linked to protein degradation and signaling dysfunctions.