Explore the Potential with AI-Driven Innovation
The focused library is created on demand with the latest virtual screening and parameter assessment technology, supported by the Receptor.AI drug discovery platform. This method is more effective than traditional methods and results in higher-quality compounds with better activity, selectivity, and safety.
The compounds are cherry-picked from the vast virtual chemical space of over 60B molecules. The synthesis and delivery of compounds is facilitated by our partner Reaxense.
The library features a range of promising modulators, each detailed with 38 ADME-Tox and 32 physicochemical and drug-likeness parameters. Plus, each compound is presented with its ideal docking poses, affinity scores, and activity scores, ensuring a thorough insight.
Our high-tech, dedicated method is applied to construct targeted libraries for enzymes.
Fig. 1. The sreening workflow of Receptor.AI
It includes comprehensive molecular simulations of the catalytic and allosteric binding pockets and the ensemble virtual screening accounting for their conformational mobility. In the case of designing modulators, the structural changes induced by reaction intermediates are taken into account to leverage activity and selectivity.
Several key aspects differentiate our library:
partner
Reaxense
upacc
Q9C098
UPID:
DCLK3_HUMAN
Alternative names:
Doublecortin domain-containing protein 3C; Doublecortin-like and CAM kinase-like 3; Doublecortin-like kinase 3
Alternative UPACC:
Q9C098
Background:
Serine/threonine-protein kinase DCLK3, also known as Doublecortin domain-containing protein 3C, Doublecortin-like and CAM kinase-like 3, and Doublecortin-like kinase 3, plays a pivotal role in cellular signaling pathways. Its unique structure, characterized by the presence of doublecortin domains, suggests a specialized function in neuronal development and signal transduction.
Therapeutic significance:
Understanding the role of Serine/threonine-protein kinase DCLK3 could open doors to potential therapeutic strategies. Its involvement in critical signaling pathways makes it a promising target for drug discovery efforts aimed at treating neurological disorders.