Explore the Potential with AI-Driven Innovation
This comprehensive focused library is produced on demand with state-of-the-art virtual screening and parameter assessment technology driven by Receptor.AI drug discovery platform. This approach outperforms traditional methods and provides higher-quality compounds with superior activity, selectivity and safety.
Our selection of compounds is from a large virtual library of over 60 billion molecules. The production and distribution of these compounds are managed by our partner Reaxense.
The library includes a list of the most effective modulators, each annotated with 38 ADME-Tox and 32 physicochemical and drug-likeness parameters. Furthermore, each compound is shown with its optimal docking poses, affinity scores, and activity scores, offering a detailed summary.
Our top-notch dedicated system is used to design specialised libraries.
Fig. 1. The sreening workflow of Receptor.AI
Utilising molecular simulations, our approach thoroughly examines a wide array of proteins, tracking their conformational changes individually and within complexes. Ensemble virtual screening enables us to address conformational flexibility, revealing essential binding sites at functional regions and allosteric locations. Our rigorous analysis guarantees that no potential mechanism of action is overlooked, aiming to uncover new therapeutic targets and lead compounds across diverse biological functions.
Key features that set our library apart include:
partner
Reaxense
upacc
Q9GZQ8
UPID:
MLP3B_HUMAN
Alternative names:
Autophagy-related protein LC3 B; Autophagy-related ubiquitin-like modifier LC3 B; MAP1 light chain 3-like protein 2; MAP1A/MAP1B light chain 3 B; Microtubule-associated protein 1 light chain 3 beta
Alternative UPACC:
Q9GZQ8; Q6NW02
Background:
Microtubule-associated proteins 1A/1B light chain 3B, also known as Autophagy-related protein LC3 B, plays a pivotal role in autophagy, aiding in the formation of autophagosomes. It is crucial for maintaining cellular homeostasis by regulating mitochondrial quantity and quality, thus preventing excess ROS production. Additionally, it facilitates mitophagy, primary ciliogenesis, and the turnover of the endoplasmic reticulum, showcasing its versatility in cellular processes.
Therapeutic significance:
Understanding the role of Microtubule-associated proteins 1A/1B light chain 3B could open doors to potential therapeutic strategies.