Explore the Potential with AI-Driven Innovation
This comprehensive focused library is produced on demand with state-of-the-art virtual screening and parameter assessment technology driven by Receptor.AI drug discovery platform. This approach outperforms traditional methods and provides higher-quality compounds with superior activity, selectivity and safety.
From a virtual chemical space containing more than 60 billion molecules, we precisely choose certain compounds. Our collaborator, Reaxense, aids in their synthesis and provision.
The library includes a list of the most promising modulators annotated with 38 ADME-Tox and 32 physicochemical and drug-likeness parameters. Also, each compound is presented with its optimal docking poses, affinity scores, and activity scores, providing a comprehensive overview.
We utilise our cutting-edge, exclusive workflow to develop focused libraries.
Fig. 1. The sreening workflow of Receptor.AI
Our methodology leverages molecular simulations to examine a vast array of proteins, capturing their dynamics in both isolated forms and in complexes with other proteins. Through ensemble virtual screening, we thoroughly account for the protein's conformational mobility, identifying critical binding sites within functional regions and distant allosteric locations. This detailed exploration ensures that we comprehensively assess every possible mechanism of action, with the objective of identifying novel therapeutic targets and lead compounds that span a wide spectrum of biological functions.
Our library distinguishes itself through several key aspects:
partner
Reaxense
upacc
Q9GZS3
UPID:
SKI8_HUMAN
Alternative names:
Meiotic recombination REC14 protein homolog; WD repeat-containing protein 61
Alternative UPACC:
Q9GZS3; D3DW84; Q6IA22; Q7Z4X4
Background:
Superkiller complex protein 8, also known as Meiotic recombination REC14 protein homolog and WD repeat-containing protein 61, plays a pivotal role in transcription regulation, embryonic stem cell pluripotency, and hematopoiesis. It is a component of the PAF1 complex, influencing transcriptional elongation, histone modification, and mRNA 3' end formation. This protein is also integral to the SKI complex, aiding in mRNA decay and quality control.
Therapeutic significance:
Understanding the role of Superkiller complex protein 8 could open doors to potential therapeutic strategies.