Explore the Potential with AI-Driven Innovation
The focused library is created on demand with the latest virtual screening and parameter assessment technology, supported by the Receptor.AI drug discovery platform. This method is more effective than traditional methods and results in higher-quality compounds with better activity, selectivity, and safety.
We carefully select specific compounds from a vast collection of over 60 billion molecules in virtual chemical space. Our partner Reaxense helps in synthesizing and delivering these compounds.
The library includes a list of the most effective modulators, each annotated with 38 ADME-Tox and 32 physicochemical and drug-likeness parameters. Furthermore, each compound is shown with its optimal docking poses, affinity scores, and activity scores, offering a detailed summary.
Our high-tech, dedicated method is applied to construct targeted libraries for enzymes.
Fig. 1. The sreening workflow of Receptor.AI
It includes comprehensive molecular simulations of the catalytic and allosteric binding pockets and the ensemble virtual screening accounting for their conformational mobility. In the case of designing modulators, the structural changes induced by reaction intermediates are taken into account to leverage activity and selectivity.
Our library stands out due to several important features:
partner
Reaxense
upacc
Q9H089
UPID:
LSG1_HUMAN
Alternative names:
-
Alternative UPACC:
Q9H089; A0JLT4; A0PJK3; A6NI18; Q7L9H8; Q9NUK8
Background:
Large subunit GTPase 1 homolog plays a crucial role in cellular processes by facilitating the nuclear export of the 60S ribosomal subunit. This protein, identified by the accession number Q9H089, is essential for the proper functioning of the ribosome, the cell's protein factory. It likely achieves this by interacting with XPO1/CRM1 exportin and ensuring the release of NMD3 from the 60S subunit in the cytoplasm.
Therapeutic significance:
Understanding the role of Large subunit GTPase 1 homolog could open doors to potential therapeutic strategies. Its pivotal function in ribosomal assembly and transport underscores its importance in cellular biology and disease mechanisms.