Explore the Potential with AI-Driven Innovation
Our detailed focused library is generated on demand with advanced virtual screening and parameter assessment technology powered by the Receptor.AI drug discovery platform. This method surpasses traditional approaches, delivering compounds of better quality with enhanced activity, selectivity, and safety.
The compounds are cherry-picked from the vast virtual chemical space of over 60B molecules. The synthesis and delivery of compounds is facilitated by our partner Reaxense.
The library includes a list of the most effective modulators, each annotated with 38 ADME-Tox and 32 physicochemical and drug-likeness parameters. Furthermore, each compound is shown with its optimal docking poses, affinity scores, and activity scores, offering a detailed summary.
We utilise our cutting-edge, exclusive workflow to develop focused libraries for enzymes.
Fig. 1. The sreening workflow of Receptor.AI
The procedure entails thorough molecular simulations of the catalytic and allosteric binding pockets, accompanied by ensemble virtual screening that factors in their conformational flexibility. When developing modulators, the structural modifications brought about by reaction intermediates are factored in to optimize activity and selectivity.
Our library is unique due to several crucial aspects:
partner
Reaxense
upacc
Q9H1B5
UPID:
XYLT2_HUMAN
Alternative names:
Peptide O-xylosyltransferase 1; Xylosyltransferase II
Alternative UPACC:
Q9H1B5; Q6UY41; Q86V00
Background:
Xylosyltransferase 2, also known as Peptide O-xylosyltransferase 1 or Xylosyltransferase II, plays a crucial role in the biosynthesis of glycosaminoglycans including chondroitin sulfate, heparan sulfate, and dermatan sulfate proteoglycans. This enzyme initiates the glycosylation process by transferring D-xylose from UDP-D-xylose to specific serine residues of the core protein.
Therapeutic significance:
Xylosyltransferase 2 is implicated in Spondyloocular syndrome and acts as a disease modifier in Pseudoxanthoma elasticum. Understanding its role could lead to novel therapeutic strategies for these conditions, highlighting its potential as a target in drug discovery efforts aimed at treating connective tissue disorders.