Explore the Potential with AI-Driven Innovation
This extensive focused library is tailor-made using the latest virtual screening and parameter assessment technology, operated by the Receptor.AI drug discovery platform. This technique is more effective than traditional methods, offering compounds with improved activity, selectivity, and safety.
Our selection of compounds is from a large virtual library of over 60 billion molecules. The production and distribution of these compounds are managed by our partner Reaxense.
Contained in the library are leading modulators, each labelled with 38 ADME-Tox and 32 physicochemical and drug-likeness qualities. In addition, each compound is illustrated with its optimal docking poses, affinity scores, and activity scores, giving a complete picture.
We employ our advanced, specialised process to create targeted libraries.
Fig. 1. The sreening workflow of Receptor.AI
By deploying molecular simulations, our approach comprehensively covers a broad array of proteins, tracking their flexibility and dynamics individually and within complexes. Ensemble virtual screening is utilised to take into account conformational dynamics, identifying pivotal binding sites located within functional regions and at allosteric locations. This thorough exploration ensures that every conceivable mechanism of action is considered, aiming to identify new therapeutic targets and advance lead compounds throughout a vast spectrum of biological functions.
Our library distinguishes itself through several key aspects:
partner
Reaxense
upacc
Q9H1I8
UPID:
ASCC2_HUMAN
Alternative names:
ASC-1 complex subunit p100; Trip4 complex subunit p100
Alternative UPACC:
Q9H1I8; B7Z8E0; F5H6J9; Q4TT54; Q8TAZ0; Q9H711; Q9H9D6
Background:
Activating signal cointegrator 1 complex subunit 2 (ASC-1 complex subunit p100) is a pivotal ubiquitin-binding protein, playing a crucial role in DNA repair and ribosome rescue. It is a part of the ASCC complex, enhancing DNA damage repair by recruiting ASCC3 and ALKBH3 to damaged sites. Additionally, it is involved in the ribosome quality control (RQC) pathway, identifying and disassembling stalled ribosomes, thus ensuring cellular fidelity.
Therapeutic significance:
Understanding the role of Activating signal cointegrator 1 complex subunit 2 could open doors to potential therapeutic strategies.