Explore the Potential with AI-Driven Innovation
The specialised, focused library is developed on demand with the most recent virtual screening and parameter assessment technology, guided by the Receptor.AI drug discovery platform. This approach exceeds the capabilities of traditional methods and offers compounds with higher activity, selectivity, and safety.
We pick out particular compounds from an extensive virtual database of more than 60 billion molecules. The preparation and shipment of these compounds are facilitated by our associate Reaxense.
In the library, a selection of top modulators is provided, each marked with 38 ADME-Tox and 32 parameters related to physicochemical properties and drug-likeness. Also, every compound comes with its best docking poses, affinity scores, and activity scores, providing a comprehensive overview.
We employ our advanced, specialised process to create targeted libraries.
Fig. 1. The sreening workflow of Receptor.AI
Our methodology employs molecular simulations to explore a wide array of proteins, capturing their dynamic states both individually and within complexes. Through ensemble virtual screening, we address conformational mobility, uncovering binding sites within functional regions and remote allosteric locations. This thorough exploration ensures no potential mechanism of action is overlooked, aiming to discover novel therapeutic targets and lead compounds across an extensive spectrum of biological functions.
Our library is unique due to several crucial aspects:
partner
Reaxense
upacc
Q9H1J5
UPID:
WNT8A_HUMAN
Alternative names:
Protein Wnt-8d
Alternative UPACC:
Q9H1J5; Q96S51
Background:
Protein Wnt-8a, alternatively known as Protein Wnt-8d, plays a pivotal role in the complex process of embryonic patterning. As a ligand for members of the frizzled family of seven transmembrane receptors, it is integral to the Wnt signaling pathway, a key regulator of cell fate determination, migration, and organogenesis.
Therapeutic significance:
Understanding the role of Protein Wnt-8a could open doors to potential therapeutic strategies. Its involvement in embryonic development suggests its potential impact on regenerative medicine and tissue engineering, offering insights into novel approaches for congenital disorders and injury repair.