Explore the Potential with AI-Driven Innovation
The focused library is created on demand with the latest virtual screening and parameter assessment technology, supported by the Receptor.AI drug discovery platform. This method is more effective than traditional methods and results in higher-quality compounds with better activity, selectivity, and safety.
We pick out particular compounds from an extensive virtual database of more than 60 billion molecules. The preparation and shipment of these compounds are facilitated by our associate Reaxense.
The library features a range of promising modulators, each detailed with 38 ADME-Tox and 32 physicochemical and drug-likeness parameters. Plus, each compound is presented with its ideal docking poses, affinity scores, and activity scores, ensuring a thorough insight.
We utilise our cutting-edge, exclusive workflow to develop focused libraries.
Fig. 1. The sreening workflow of Receptor.AI
Our strategy employs molecular simulations to explore an extensive range of proteins, capturing their dynamics both individually and within complexes with other proteins. Through ensemble virtual screening, we address proteins' conformational mobility, uncovering key binding sites at both functional regions and remote allosteric locations. This comprehensive investigation ensures a thorough assessment of all potential mechanisms of action, with the goal of discovering innovative therapeutic targets and lead molecules across across diverse biological functions.
Several key aspects differentiate our library:
partner
Reaxense
upacc
Q9H252
UPID:
KCNH6_HUMAN
Alternative names:
Ether-a-go-go-related gene potassium channel 2; Voltage-gated potassium channel subunit Kv11.2
Alternative UPACC:
Q9H252; Q9BRD7
Background:
The Potassium voltage-gated channel subfamily H member 6, also known as Ether-a-go-go-related gene potassium channel 2 and Voltage-gated potassium channel subunit Kv11.2, plays a crucial role in cellular electrophysiology. It forms the pore-forming (alpha) subunit of voltage-gated potassium channels, eliciting a slowly activating, rectifying current. This channel's properties can be influenced by cAMP and its subunit assembly.
Therapeutic significance:
Understanding the role of Potassium voltage-gated channel subfamily H member 6 could open doors to potential therapeutic strategies.