Explore the Potential with AI-Driven Innovation
Our detailed focused library is generated on demand with advanced virtual screening and parameter assessment technology powered by the Receptor.AI drug discovery platform. This method surpasses traditional approaches, delivering compounds of better quality with enhanced activity, selectivity, and safety.
We pick out particular compounds from an extensive virtual database of more than 60 billion molecules. The preparation and shipment of these compounds are facilitated by our associate Reaxense.
In the library, a selection of top modulators is provided, each marked with 38 ADME-Tox and 32 parameters related to physicochemical properties and drug-likeness. Also, every compound comes with its best docking poses, affinity scores, and activity scores, providing a comprehensive overview.
We use our state-of-the-art dedicated workflow for designing focused libraries.
Fig. 1. The sreening workflow of Receptor.AI
Our methodology leverages molecular simulations to examine a vast array of proteins, capturing their dynamics in both isolated forms and in complexes with other proteins. Through ensemble virtual screening, we thoroughly account for the protein's conformational mobility, identifying critical binding sites within functional regions and distant allosteric locations. This detailed exploration ensures that we comprehensively assess every possible mechanism of action, with the objective of identifying novel therapeutic targets and lead compounds that span a wide spectrum of biological functions.
Key features that set our library apart include:
partner
Reaxense
upacc
Q9H2D1
UPID:
MFTC_HUMAN
Alternative names:
Solute carrier family 25 member 32
Alternative UPACC:
Q9H2D1; A0A024R9D0; Q96JZ6; Q96SU7
Background:
The Mitochondrial folate transporter/carrier, also known as Solute carrier family 25 member 32, plays a crucial role in cellular metabolism by transporting folate and FAD across the inner membranes of mitochondria. This process is vital for numerous metabolic pathways, including those involved in the synthesis of nucleotides and the maintenance of mitochondrial function.
Therapeutic significance:
Given its involvement in exercise intolerance, riboflavin-responsive, and neural tube defects, understanding the role of the Mitochondrial folate transporter/carrier could open doors to potential therapeutic strategies. Targeting this protein may offer new avenues for treating these conditions, which have genetic and environmental components.