Explore the Potential with AI-Driven Innovation
Our detailed focused library is generated on demand with advanced virtual screening and parameter assessment technology powered by the Receptor.AI drug discovery platform. This method surpasses traditional approaches, delivering compounds of better quality with enhanced activity, selectivity, and safety.
We pick out particular compounds from an extensive virtual database of more than 60 billion molecules. The preparation and shipment of these compounds are facilitated by our associate Reaxense.
The library includes a list of the most effective modulators, each annotated with 38 ADME-Tox and 32 physicochemical and drug-likeness parameters. Furthermore, each compound is shown with its optimal docking poses, affinity scores, and activity scores, offering a detailed summary.
Our high-tech, dedicated method is applied to construct targeted libraries.
Fig. 1. The sreening workflow of Receptor.AI
Our methodology employs molecular simulations to explore a wide array of proteins, capturing their dynamic states both individually and within complexes. Through ensemble virtual screening, we address conformational mobility, uncovering binding sites within functional regions and remote allosteric locations. This thorough exploration ensures no potential mechanism of action is overlooked, aiming to discover novel therapeutic targets and lead compounds across an extensive spectrum of biological functions.
Several key aspects differentiate our library:
partner
Reaxense
upacc
Q9H2H0
UPID:
CXXC4_HUMAN
Alternative names:
Inhibition of the Dvl and axin complex protein
Alternative UPACC:
Q9H2H0
Background:
CXXC-type zinc finger protein 4, alternatively known as Inhibition of the Dvl and axin complex protein, plays a crucial role in the Wnt signaling pathway by negatively regulating it through interaction with DVL1. This protein has a preference for binding to DNA containing cytidine-phosphate-guanosine (CpG) dinucleotides, showcasing specificity towards hemimethylated-CpG and hemimethylated-hydroxymethyl-CpG.
Therapeutic significance:
Understanding the role of CXXC-type zinc finger protein 4 could open doors to potential therapeutic strategies.