Explore the Potential with AI-Driven Innovation
Our detailed focused library is generated on demand with advanced virtual screening and parameter assessment technology powered by the Receptor.AI drug discovery platform. This method surpasses traditional approaches, delivering compounds of better quality with enhanced activity, selectivity, and safety.
We pick out particular compounds from an extensive virtual database of more than 60 billion molecules. The preparation and shipment of these compounds are facilitated by our associate Reaxense.
Contained in the library are leading modulators, each labelled with 38 ADME-Tox and 32 physicochemical and drug-likeness qualities. In addition, each compound is illustrated with its optimal docking poses, affinity scores, and activity scores, giving a complete picture.
We employ our advanced, specialised process to create targeted libraries.
Fig. 1. The sreening workflow of Receptor.AI
By deploying molecular simulations, our approach comprehensively covers a broad array of proteins, tracking their flexibility and dynamics individually and within complexes. Ensemble virtual screening is utilised to take into account conformational dynamics, identifying pivotal binding sites located within functional regions and at allosteric locations. This thorough exploration ensures that every conceivable mechanism of action is considered, aiming to identify new therapeutic targets and advance lead compounds throughout a vast spectrum of biological functions.
Our library is unique due to several crucial aspects:
partner
Reaxense
upacc
Q9H3U1
UPID:
UN45A_HUMAN
Alternative names:
GCUNC-45; Smooth muscle cell-associated protein 1
Alternative UPACC:
Q9H3U1; A8K6F7; Q7L3Y6; Q9H3U8; Q9NSE8; Q9NSE9
Background:
Protein unc-45 homolog A, also known as GCUNC-45 and Smooth muscle cell-associated protein 1, plays a crucial role in cellular processes. It acts as a co-chaperone for HSP90, regulating ATPase activity and promoting PGR function. This protein is essential for proper myosin folding, cell proliferation, myotube formation, and muscle cell development. It may also contribute to erythropoiesis in the spleen.
Therapeutic significance:
Osteootohepatoenteric syndrome, a disorder linked to this protein, highlights its clinical relevance. Understanding the role of Protein unc-45 homolog A could open doors to potential therapeutic strategies for treating this syndrome and improving patient outcomes.