Explore the Potential with AI-Driven Innovation
The specialised, focused library is developed on demand with the most recent virtual screening and parameter assessment technology, guided by the Receptor.AI drug discovery platform. This approach exceeds the capabilities of traditional methods and offers compounds with higher activity, selectivity, and safety.
From a virtual chemical space containing more than 60 billion molecules, we precisely choose certain compounds. Our collaborator, Reaxense, aids in their synthesis and provision.
The library includes a list of the most promising modulators annotated with 38 ADME-Tox and 32 physicochemical and drug-likeness parameters. Also, each compound is presented with its optimal docking poses, affinity scores, and activity scores, providing a comprehensive overview.
Our top-notch dedicated system is used to design specialised libraries for enzymes.
Fig. 1. The sreening workflow of Receptor.AI
The procedure entails thorough molecular simulations of the catalytic and allosteric binding pockets, accompanied by ensemble virtual screening that factors in their conformational flexibility. When developing modulators, the structural modifications brought about by reaction intermediates are factored in to optimize activity and selectivity.
Our library is unique due to several crucial aspects:
partner
Reaxense
upacc
Q9H4A4
UPID:
AMPB_HUMAN
Alternative names:
Arginine aminopeptidase; Arginyl aminopeptidase
Alternative UPACC:
Q9H4A4; Q9BVM9; Q9H1D4; Q9NPT7
Background:
Aminopeptidase B, also known as Arginine aminopeptidase or Arginyl aminopeptidase, plays a crucial role in protein metabolism by selectively removing arginine and/or lysine residues from the N-terminus of peptides. This enzyme's ability to hydrolyze leukotriene A4 into leukotriene B4 highlights its significance in inflammatory processes.
Therapeutic significance:
Understanding the role of Aminopeptidase B could open doors to potential therapeutic strategies. Its involvement in peptide modification and inflammation suggests avenues for drug discovery, particularly in conditions where peptide signaling and inflammation play critical roles.