Explore the Potential with AI-Driven Innovation
Our detailed focused library is generated on demand with advanced virtual screening and parameter assessment technology powered by the Receptor.AI drug discovery platform. This method surpasses traditional approaches, delivering compounds of better quality with enhanced activity, selectivity, and safety.
The compounds are cherry-picked from the vast virtual chemical space of over 60B molecules. The synthesis and delivery of compounds is facilitated by our partner Reaxense.
The library features a range of promising modulators, each detailed with 38 ADME-Tox and 32 physicochemical and drug-likeness parameters. Plus, each compound is presented with its ideal docking poses, affinity scores, and activity scores, ensuring a thorough insight.
Our top-notch dedicated system is used to design specialised libraries.
Fig. 1. The sreening workflow of Receptor.AI
By deploying molecular simulations, our approach comprehensively covers a broad array of proteins, tracking their flexibility and dynamics individually and within complexes. Ensemble virtual screening is utilised to take into account conformational dynamics, identifying pivotal binding sites located within functional regions and at allosteric locations. This thorough exploration ensures that every conceivable mechanism of action is considered, aiming to identify new therapeutic targets and advance lead compounds throughout a vast spectrum of biological functions.
Our library stands out due to several important features:
partner
Reaxense
upacc
Q9H4G0
UPID:
E41L1_HUMAN
Alternative names:
Erythrocyte membrane protein band 4.1-like 1; Neuronal protein 4.1
Alternative UPACC:
Q9H4G0; O15046; Q4VXM6; Q4VXM7; Q4VXM8; Q4VXN4; Q6ZT61; Q8IUU7; Q96CV5; Q96L65
Background:
Band 4.1-like protein 1, also known as Erythrocyte membrane protein band 4.1-like 1 or Neuronal protein 4.1, plays a crucial role in neuronal membrane stability and plasticity. It achieves this through interactions with the spectrin-actin-based cytoskeleton, integral membrane channels, and membrane-associated guanylate kinases.
Therapeutic significance:
Linked to Intellectual developmental disorder, autosomal dominant 11, Band 4.1-like protein 1's understanding could pave the way for innovative therapeutic strategies targeting neuronal membrane stability and intellectual developmental disorders.