Explore the Potential with AI-Driven Innovation
This extensive focused library is tailor-made using the latest virtual screening and parameter assessment technology, operated by the Receptor.AI drug discovery platform. This technique is more effective than traditional methods, offering compounds with improved activity, selectivity, and safety.
We pick out particular compounds from an extensive virtual database of more than 60 billion molecules. The preparation and shipment of these compounds are facilitated by our associate Reaxense.
The library features a range of promising modulators, each detailed with 38 ADME-Tox and 32 physicochemical and drug-likeness parameters. Plus, each compound is presented with its ideal docking poses, affinity scores, and activity scores, ensuring a thorough insight.
We use our state-of-the-art dedicated workflow for designing focused libraries.
Fig. 1. The sreening workflow of Receptor.AI
Utilising molecular simulations, our approach thoroughly examines a wide array of proteins, tracking their conformational changes individually and within complexes. Ensemble virtual screening enables us to address conformational flexibility, revealing essential binding sites at functional regions and allosteric locations. Our rigorous analysis guarantees that no potential mechanism of action is overlooked, aiming to uncover new therapeutic targets and lead compounds across diverse biological functions.
Our library distinguishes itself through several key aspects:
partner
Reaxense
upacc
Q9H4I9
UPID:
EMRE_HUMAN
Alternative names:
Single-pass membrane protein with aspartate-rich tail 1, mitochondrial
Alternative UPACC:
Q9H4I9; B2R5D1; Q8TAB9
Background:
The Essential MCU regulator, mitochondrial, also known as Single-pass membrane protein with aspartate-rich tail 1, is a pivotal component of the mitochondrial calcium uniporter complex. This protein is indispensable for calcium uptake into mitochondria, acting as a bridge between calcium-sensing proteins MICU1 and MICU2 and the calcium-conducting subunit MCU. It plays a crucial role in the regulation of the uniporter complex's response to intracellular calcium signaling, ensuring tight control and appropriate responses.
Therapeutic significance:
Understanding the role of the Essential MCU regulator, mitochondrial could open doors to potential therapeutic strategies.