Explore the Potential with AI-Driven Innovation
The focused library is created on demand with the latest virtual screening and parameter assessment technology, supported by the Receptor.AI drug discovery platform. This method is more effective than traditional methods and results in higher-quality compounds with better activity, selectivity, and safety.
The compounds are cherry-picked from the vast virtual chemical space of over 60B molecules. The synthesis and delivery of compounds is facilitated by our partner Reaxense.
The library features a range of promising modulators, each detailed with 38 ADME-Tox and 32 physicochemical and drug-likeness parameters. Plus, each compound is presented with its ideal docking poses, affinity scores, and activity scores, ensuring a thorough insight.
We employ our advanced, specialised process to create targeted libraries.
Fig. 1. The sreening workflow of Receptor.AI
Utilising molecular simulations, our approach thoroughly examines a wide array of proteins, tracking their conformational changes individually and within complexes. Ensemble virtual screening enables us to address conformational flexibility, revealing essential binding sites at functional regions and allosteric locations. Our rigorous analysis guarantees that no potential mechanism of action is overlooked, aiming to uncover new therapeutic targets and lead compounds across diverse biological functions.
Our library distinguishes itself through several key aspects:
partner
Reaxense
upacc
Q9H5P4
UPID:
PDZD7_HUMAN
Alternative names:
-
Alternative UPACC:
Q9H5P4; D5FJ77; Q8N321
Background:
PDZ domain-containing protein 7 plays a pivotal role in cochlear hair cell development, crucial for organizing the USH2 complex at stereocilia ankle links. It also negates ADGRV1-mediated inhibition of adenylate cyclase activity, highlighting its multifunctionality in cellular processes.
Therapeutic significance:
Linked to Deafness, autosomal recessive, 57, and Usher syndrome types 2A and 2C, understanding PDZ domain-containing protein 7's role could unveil new therapeutic avenues for these sensorineural conditions.