Explore the Potential with AI-Driven Innovation
The specialised, focused library is developed on demand with the most recent virtual screening and parameter assessment technology, guided by the Receptor.AI drug discovery platform. This approach exceeds the capabilities of traditional methods and offers compounds with higher activity, selectivity, and safety.
The compounds are cherry-picked from the vast virtual chemical space of over 60B molecules. The synthesis and delivery of compounds is facilitated by our partner Reaxense.
Contained in the library are leading modulators, each labelled with 38 ADME-Tox and 32 physicochemical and drug-likeness qualities. In addition, each compound is illustrated with its optimal docking poses, affinity scores, and activity scores, giving a complete picture.
We use our state-of-the-art dedicated workflow for designing focused libraries.
Fig. 1. The sreening workflow of Receptor.AI
By deploying molecular simulations, our approach comprehensively covers a broad array of proteins, tracking their flexibility and dynamics individually and within complexes. Ensemble virtual screening is utilised to take into account conformational dynamics, identifying pivotal binding sites located within functional regions and at allosteric locations. This thorough exploration ensures that every conceivable mechanism of action is considered, aiming to identify new therapeutic targets and advance lead compounds throughout a vast spectrum of biological functions.
Our library distinguishes itself through several key aspects:
partner
Reaxense
upacc
Q9H5V7
UPID:
IKZF5_HUMAN
Alternative names:
Ikaros family zinc finger protein 5
Alternative UPACC:
Q9H5V7; B3KVH7; D3DRE7; Q9H2T0
Background:
Zinc finger protein Pegasus, also known as Ikaros family zinc finger protein 5, plays a crucial role in transcriptional repression, binding the core DNA consensus sequence to influence gene expression. Its involvement in megakaryocyte differentiation highlights its importance in the hematopoietic system.
Therapeutic significance:
The protein's association with Thrombocytopenia 7, a disorder characterized by a reduced platelet count leading to bleeding risks, underscores its potential as a target for therapeutic intervention. Understanding the role of Zinc finger protein Pegasus could open doors to potential therapeutic strategies.