Explore the Potential with AI-Driven Innovation
The focused library is created on demand with the latest virtual screening and parameter assessment technology, supported by the Receptor.AI drug discovery platform. This method is more effective than traditional methods and results in higher-quality compounds with better activity, selectivity, and safety.
The compounds are cherry-picked from the vast virtual chemical space of over 60B molecules. The synthesis and delivery of compounds is facilitated by our partner Reaxense.
The library includes a list of the most effective modulators, each annotated with 38 ADME-Tox and 32 physicochemical and drug-likeness parameters. Furthermore, each compound is shown with its optimal docking poses, affinity scores, and activity scores, offering a detailed summary.
Our high-tech, dedicated method is applied to construct targeted libraries.
Fig. 1. The sreening workflow of Receptor.AI
Our methodology employs molecular simulations to explore a wide array of proteins, capturing their dynamic states both individually and within complexes. Through ensemble virtual screening, we address conformational mobility, uncovering binding sites within functional regions and remote allosteric locations. This thorough exploration ensures no potential mechanism of action is overlooked, aiming to discover novel therapeutic targets and lead compounds across an extensive spectrum of biological functions.
Our library is unique due to several crucial aspects:
partner
Reaxense
upacc
Q9H5V9
UPID:
STEEP_HUMAN
Alternative names:
-
Alternative UPACC:
Q9H5V9; A8MPX7; B4DQN2; D3DWH9; F5GWL7; O43351
Background:
The STING ER exit protein plays a pivotal role in cellular processes by facilitating membrane curvature and the establishment of endoplasmic reticulum exit sites (ERES). This action is crucial for COPII vesicle-mediated transport, a fundamental step in the secretory pathway. Additionally, it aids in the endoplasmic reticulum exit of cGAMP-activated STING1 oligomers, highlighting its importance in intracellular signaling pathways.
Therapeutic significance:
Given its involvement in Intellectual developmental disorder, X-linked 107, the STING ER exit protein presents a promising target for therapeutic intervention. Understanding the role of STING ER exit protein could open doors to potential therapeutic strategies.