Explore the Potential with AI-Driven Innovation
Our detailed focused library is generated on demand with advanced virtual screening and parameter assessment technology powered by the Receptor.AI drug discovery platform. This method surpasses traditional approaches, delivering compounds of better quality with enhanced activity, selectivity, and safety.
From a virtual chemical space containing more than 60 billion molecules, we precisely choose certain compounds. Our collaborator, Reaxense, aids in their synthesis and provision.
The library includes a list of the most effective modulators, each annotated with 38 ADME-Tox and 32 physicochemical and drug-likeness parameters. Furthermore, each compound is shown with its optimal docking poses, affinity scores, and activity scores, offering a detailed summary.
We use our state-of-the-art dedicated workflow for designing focused libraries for enzymes.
Fig. 1. The sreening workflow of Receptor.AI
It includes comprehensive molecular simulations of the catalytic and allosteric binding pockets and the ensemble virtual screening accounting for their conformational mobility. In the case of designing modulators, the structural changes induced by reaction intermediates are taken into account to leverage activity and selectivity.
Our library is unique due to several crucial aspects:
partner
Reaxense
upacc
Q9H5Z1
UPID:
DHX35_HUMAN
Alternative names:
DEAH box protein 35
Alternative UPACC:
Q9H5Z1; A2RTX3; B4E0J0; F5GXM6; Q5THR0; Q9H4H7; Q9H6T6
Background:
The Probable ATP-dependent RNA helicase DHX35, also known as DEAH box protein 35, plays a crucial role in cellular processes by potentially being involved in pre-mRNA splicing. This protein is part of the helicase family, which unwinds RNA, a critical step in RNA processing and metabolism.
Therapeutic significance:
Understanding the role of Probable ATP-dependent RNA helicase DHX35 could open doors to potential therapeutic strategies. Its involvement in RNA processing suggests it could be a target for diseases where RNA splicing is affected.