Explore the Potential with AI-Driven Innovation
Our detailed focused library is generated on demand with advanced virtual screening and parameter assessment technology powered by the Receptor.AI drug discovery platform. This method surpasses traditional approaches, delivering compounds of better quality with enhanced activity, selectivity, and safety.
Our selection of compounds is from a large virtual library of over 60 billion molecules. The production and distribution of these compounds are managed by our partner Reaxense.
Contained in the library are leading modulators, each labelled with 38 ADME-Tox and 32 physicochemical and drug-likeness qualities. In addition, each compound is illustrated with its optimal docking poses, affinity scores, and activity scores, giving a complete picture.
Our top-notch dedicated system is used to design specialised libraries.
Fig. 1. The sreening workflow of Receptor.AI
Our strategy employs molecular simulations to explore an extensive range of proteins, capturing their dynamics both individually and within complexes with other proteins. Through ensemble virtual screening, we address proteins' conformational mobility, uncovering key binding sites at both functional regions and remote allosteric locations. This comprehensive investigation ensures a thorough assessment of all potential mechanisms of action, with the goal of discovering innovative therapeutic targets and lead molecules across across diverse biological functions.
Our library is unique due to several crucial aspects:
partner
Reaxense
upacc
Q9H6Q3
UPID:
SLAP2_HUMAN
Alternative names:
Modulator of antigen receptor signaling; Src-like adapter protein 2
Alternative UPACC:
Q9H6Q3; A8K648; E1P5U1; E1P5U2; Q5TH27; Q5TH28; Q8WY18; Q96QI4; Q9H135
Background:
Src-like-adapter 2, also known as Modulator of antigen receptor signaling, plays a crucial role in the immune system. It functions as an adapter protein that negatively regulates T-cell receptor (TCR) signaling, inhibiting T-cell antigen-receptor induced activation of nuclear factor of activated T-cells. This protein acts by linking signaling proteins such as ZAP70 with CBL, leading to a CBL dependent degradation of signaling proteins.
Therapeutic significance:
Understanding the role of Src-like-adapter 2 could open doors to potential therapeutic strategies.