Explore the Potential with AI-Driven Innovation
This comprehensive focused library is produced on demand with state-of-the-art virtual screening and parameter assessment technology driven by Receptor.AI drug discovery platform. This approach outperforms traditional methods and provides higher-quality compounds with superior activity, selectivity and safety.
Our selection of compounds is from a large virtual library of over 60 billion molecules. The production and distribution of these compounds are managed by our partner Reaxense.
The library includes a list of the most effective modulators, each annotated with 38 ADME-Tox and 32 physicochemical and drug-likeness parameters. Furthermore, each compound is shown with its optimal docking poses, affinity scores, and activity scores, offering a detailed summary.
We use our state-of-the-art dedicated workflow for designing focused libraries for enzymes.
Fig. 1. The sreening workflow of Receptor.AI
This approach involves comprehensive molecular simulations of the catalytic and allosteric binding pockets and ensemble virtual screening that accounts for their conformational flexibility. In the case of designing modulators, the structural adjustments caused by reaction intermediates are considered to improve activity and selectivity.
Several key aspects differentiate our library:
partner
Reaxense
upacc
Q9H790
UPID:
EXO5_HUMAN
Alternative names:
Defects in morphology protein 1 homolog
Alternative UPACC:
Q9H790; D3DPV4; Q5SWM7; Q5SWM8; Q5SWM9; Q5SWN0; Q5SWN1; Q8WTW9
Background:
Exonuclease V, also known as Defects in morphology protein 1 homolog, plays a crucial role in DNA repair mechanisms. It exhibits bidirectional exonuclease activity, primarily involved in repairing DNA damage caused by ultraviolet irradiation and interstrand cross-links. This protein uniquely combines both 5'-3' and 3'-5' exonuclease activities, favoring 5'-ends, and demonstrates a sliding exonuclease function that is pivotal for DNA repair processes.
Therapeutic significance:
Understanding the role of Exonuclease V could open doors to potential therapeutic strategies. Its involvement in DNA repair mechanisms highlights its significance in maintaining genomic stability, which is essential for preventing the onset of various diseases.