Explore the Potential with AI-Driven Innovation
The focused library is created on demand with the latest virtual screening and parameter assessment technology, supported by the Receptor.AI drug discovery platform. This method is more effective than traditional methods and results in higher-quality compounds with better activity, selectivity, and safety.
From a virtual chemical space containing more than 60 billion molecules, we precisely choose certain compounds. Our collaborator, Reaxense, aids in their synthesis and provision.
Contained in the library are leading modulators, each labelled with 38 ADME-Tox and 32 physicochemical and drug-likeness qualities. In addition, each compound is illustrated with its optimal docking poses, affinity scores, and activity scores, giving a complete picture.
We utilise our cutting-edge, exclusive workflow to develop focused libraries.
Fig. 1. The sreening workflow of Receptor.AI
Our methodology employs molecular simulations to explore a wide array of proteins, capturing their dynamic states both individually and within complexes. Through ensemble virtual screening, we address conformational mobility, uncovering binding sites within functional regions and remote allosteric locations. This thorough exploration ensures no potential mechanism of action is overlooked, aiming to discover novel therapeutic targets and lead compounds across an extensive spectrum of biological functions.
Key features that set our library apart include:
partner
Reaxense
upacc
Q9H7X7
UPID:
IFT22_HUMAN
Alternative names:
Rab-like protein 5
Alternative UPACC:
Q9H7X7; Q49AG1; Q69YV5; Q9BSW4
Background:
Intraflagellar transport protein 22 homolog, also known as Rab-like protein 5, plays a crucial role as a small GTPase-like component of the intraflagellar transport (IFT) complex B. This protein is pivotal in the assembly and maintenance of cilia, cellular structures essential for movement and signaling.
Therapeutic significance:
Understanding the role of Intraflagellar transport protein 22 homolog could open doors to potential therapeutic strategies. Its involvement in the intricate process of cilia function highlights its potential as a target for treating ciliopathies and other related disorders.