Explore the Potential with AI-Driven Innovation
Our detailed focused library is generated on demand with advanced virtual screening and parameter assessment technology powered by the Receptor.AI drug discovery platform. This method surpasses traditional approaches, delivering compounds of better quality with enhanced activity, selectivity, and safety.
From a virtual chemical space containing more than 60 billion molecules, we precisely choose certain compounds. Our collaborator, Reaxense, aids in their synthesis and provision.
The library includes a list of the most promising modulators annotated with 38 ADME-Tox and 32 physicochemical and drug-likeness parameters. Also, each compound is presented with its optimal docking poses, affinity scores, and activity scores, providing a comprehensive overview.
Our top-notch dedicated system is used to design specialised libraries for enzymes.
Fig. 1. The sreening workflow of Receptor.AI
The procedure entails thorough molecular simulations of the catalytic and allosteric binding pockets, accompanied by ensemble virtual screening that factors in their conformational flexibility. When developing modulators, the structural modifications brought about by reaction intermediates are factored in to optimize activity and selectivity.
Our library distinguishes itself through several key aspects:
partner
Reaxense
upacc
Q9H825
UPID:
METL8_HUMAN
Alternative names:
Methyltransferase-like protein 8; mRNA N(3)-methylcytidine methyltransferase METTL8
Alternative UPACC:
Q9H825; Q53TM9; Q53TQ0
Background:
tRNA N(3)-methylcytidine methyltransferase METTL8, mitochondrial, also known as Methyltransferase-like protein 8, plays a crucial role in mitochondrial function. It is responsible for the N(3)-methylcytidine modification of mitochondrial tRNA(Ser)(UCN) and tRNA(Thr), enhancing mitochondrial translation efficiency and respiratory chain activity. This modification depends on the formation of N(6)-dimethylallyladenosine(37) by TRIT1.
Therapeutic significance:
Understanding the role of tRNA N(3)-methylcytidine methyltransferase METTL8, mitochondrial could open doors to potential therapeutic strategies.