Explore the Potential with AI-Driven Innovation
The focused library is created on demand with the latest virtual screening and parameter assessment technology, supported by the Receptor.AI drug discovery platform. This method is more effective than traditional methods and results in higher-quality compounds with better activity, selectivity, and safety.
We carefully select specific compounds from a vast collection of over 60 billion molecules in virtual chemical space. Our partner Reaxense helps in synthesizing and delivering these compounds.
In the library, a selection of top modulators is provided, each marked with 38 ADME-Tox and 32 parameters related to physicochemical properties and drug-likeness. Also, every compound comes with its best docking poses, affinity scores, and activity scores, providing a comprehensive overview.
We use our state-of-the-art dedicated workflow for designing focused libraries.
Fig. 1. The sreening workflow of Receptor.AI
Utilising molecular simulations, our approach thoroughly examines a wide array of proteins, tracking their conformational changes individually and within complexes. Ensemble virtual screening enables us to address conformational flexibility, revealing essential binding sites at functional regions and allosteric locations. Our rigorous analysis guarantees that no potential mechanism of action is overlooked, aiming to uncover new therapeutic targets and lead compounds across diverse biological functions.
Several key aspects differentiate our library:
partner
Reaxense
upacc
Q9H840
UPID:
GEMI7_HUMAN
Alternative names:
SIP3
Alternative UPACC:
Q9H840; Q6IA34
Background:
Gem-associated protein 7 (SIP3) is pivotal in the assembly of small nuclear ribonucleoproteins (snRNPs), essential components of the spliceosome. This process is crucial for the splicing of pre-mRNAs, influencing gene expression. The SMN complex, with which SIP3 is associated, facilitates the formation of snRNP by orchestrating the assembly of Sm proteins into a heptameric ring, a fundamental step in spliceosome construction.
Therapeutic significance:
Understanding the role of Gem-associated protein 7 could open doors to potential therapeutic strategies.