Explore the Potential with AI-Driven Innovation
Our detailed focused library is generated on demand with advanced virtual screening and parameter assessment technology powered by the Receptor.AI drug discovery platform. This method surpasses traditional approaches, delivering compounds of better quality with enhanced activity, selectivity, and safety.
We carefully select specific compounds from a vast collection of over 60 billion molecules in virtual chemical space. Our partner Reaxense helps in synthesizing and delivering these compounds.
Contained in the library are leading modulators, each labelled with 38 ADME-Tox and 32 physicochemical and drug-likeness qualities. In addition, each compound is illustrated with its optimal docking poses, affinity scores, and activity scores, giving a complete picture.
Our high-tech, dedicated method is applied to construct targeted libraries.
Fig. 1. The sreening workflow of Receptor.AI
Our strategy employs molecular simulations to explore an extensive range of proteins, capturing their dynamics both individually and within complexes with other proteins. Through ensemble virtual screening, we address proteins' conformational mobility, uncovering key binding sites at both functional regions and remote allosteric locations. This comprehensive investigation ensures a thorough assessment of all potential mechanisms of action, with the goal of discovering innovative therapeutic targets and lead molecules across across diverse biological functions.
Our library stands out due to several important features:
partner
Reaxense
upacc
Q9H8W4
UPID:
PKHF2_HUMAN
Alternative names:
Endoplasmic reticulum-associated apoptosis-involved protein containing PH and FYVE domains; PH and FYVE domain-containing protein 2; Phafin-2; Zinc finger FYVE domain-containing protein 18
Alternative UPACC:
Q9H8W4
Background:
Pleckstrin homology domain-containing family F member 2 (PHF2), also known as Phafin-2 and Zinc finger FYVE domain-containing protein 18, is implicated in early endosome fusion, regulating receptor trafficking and fluid-phase transport. It enhances cellular sensitivity to TNF-induced apoptosis, highlighting its role in cellular apoptosis pathways.
Therapeutic significance:
Understanding the role of Pleckstrin homology domain-containing family F member 2 could open doors to potential therapeutic strategies.