Explore the Potential with AI-Driven Innovation
The focused library is created on demand with the latest virtual screening and parameter assessment technology, supported by the Receptor.AI drug discovery platform. This method is more effective than traditional methods and results in higher-quality compounds with better activity, selectivity, and safety.
From a virtual chemical space containing more than 60 billion molecules, we precisely choose certain compounds. Our collaborator, Reaxense, aids in their synthesis and provision.
The library features a range of promising modulators, each detailed with 38 ADME-Tox and 32 physicochemical and drug-likeness parameters. Plus, each compound is presented with its ideal docking poses, affinity scores, and activity scores, ensuring a thorough insight.
We employ our advanced, specialised process to create targeted libraries.
Fig. 1. The sreening workflow of Receptor.AI
Our methodology employs molecular simulations to explore a wide array of proteins, capturing their dynamic states both individually and within complexes. Through ensemble virtual screening, we address conformational mobility, uncovering binding sites within functional regions and remote allosteric locations. This thorough exploration ensures no potential mechanism of action is overlooked, aiming to discover novel therapeutic targets and lead compounds across an extensive spectrum of biological functions.
Our library distinguishes itself through several key aspects:
partner
Reaxense
upacc
Q9H900
UPID:
ZWILC_HUMAN
Alternative names:
-
Alternative UPACC:
Q9H900; B3KVB8; Q6N049; Q8N404; Q96SY7; Q9NWG7
Background:
Protein zwilch homolog plays a pivotal role in cell division, acting as an essential component of the mitotic checkpoint. It ensures cells do not exit mitosis prematurely by facilitating the assembly of dynein-dynactin and MAD1-MAD2 complexes onto kinetochores. Its association with the mitotic RZZ complex is crucial for the spindle assembly machinery's function.
Therapeutic significance:
Understanding the role of Protein zwilch homolog could open doors to potential therapeutic strategies.