Explore the Potential with AI-Driven Innovation
The specialised, focused library is developed on demand with the most recent virtual screening and parameter assessment technology, guided by the Receptor.AI drug discovery platform. This approach exceeds the capabilities of traditional methods and offers compounds with higher activity, selectivity, and safety.
We pick out particular compounds from an extensive virtual database of more than 60 billion molecules. The preparation and shipment of these compounds are facilitated by our associate Reaxense.
The library includes a list of the most effective modulators, each annotated with 38 ADME-Tox and 32 physicochemical and drug-likeness parameters. Furthermore, each compound is shown with its optimal docking poses, affinity scores, and activity scores, offering a detailed summary.
We utilise our cutting-edge, exclusive workflow to develop focused libraries.
Fig. 1. The sreening workflow of Receptor.AI
By deploying molecular simulations, our approach comprehensively covers a broad array of proteins, tracking their flexibility and dynamics individually and within complexes. Ensemble virtual screening is utilised to take into account conformational dynamics, identifying pivotal binding sites located within functional regions and at allosteric locations. This thorough exploration ensures that every conceivable mechanism of action is considered, aiming to identify new therapeutic targets and advance lead compounds throughout a vast spectrum of biological functions.
Our library distinguishes itself through several key aspects:
partner
Reaxense
upacc
Q9H944
UPID:
MED20_HUMAN
Alternative names:
Mediator complex subunit 20; TRF-proximal protein homolog
Alternative UPACC:
Q9H944; B4DE08; O95821; Q5T8J4; Q9Y429
Background:
Mediator of RNA polymerase II transcription subunit 20, also known as Mediator complex subunit 20 and TRF-proximal protein homolog, plays a pivotal role in the transcription of RNA polymerase II-dependent genes. It acts as a coactivator, facilitating the transfer of information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. By directly interacting with regulatory proteins, it recruits the Mediator complex to promoters, serving as a scaffold for preinitiation complex assembly.
Therapeutic significance:
Understanding the role of Mediator of RNA polymerase II transcription subunit 20 could open doors to potential therapeutic strategies.