Explore the Potential with AI-Driven Innovation
The focused library is created on demand with the latest virtual screening and parameter assessment technology, supported by the Receptor.AI drug discovery platform. This method is more effective than traditional methods and results in higher-quality compounds with better activity, selectivity, and safety.
Our selection of compounds is from a large virtual library of over 60 billion molecules. The production and distribution of these compounds are managed by our partner Reaxense.
The library features a range of promising modulators, each detailed with 38 ADME-Tox and 32 physicochemical and drug-likeness parameters. Plus, each compound is presented with its ideal docking poses, affinity scores, and activity scores, ensuring a thorough insight.
Our high-tech, dedicated method is applied to construct targeted libraries for enzymes.
Fig. 1. The sreening workflow of Receptor.AI
The method includes detailed molecular simulations of the catalytic and allosteric binding pockets, along with ensemble virtual screening that considers their conformational flexibility. In the design of modulators, structural changes induced by reaction intermediates are taken into account to enhance activity and selectivity.
Our library is unique due to several crucial aspects:
partner
Reaxense
upacc
Q9H9J4
UPID:
UBP42_HUMAN
Alternative names:
Deubiquitinating enzyme 42; Ubiquitin thioesterase 42; Ubiquitin-specific-processing protease 42
Alternative UPACC:
Q9H9J4; A2RUE3; B5MDA5; Q0VIN8; Q3C166; Q6P9B4
Background:
Ubiquitin carboxyl-terminal hydrolase 42, also known as Deubiquitinating enzyme 42, Ubiquitin thioesterase 42, and Ubiquitin-specific-processing protease 42, plays a pivotal role in spermatogenesis. Its enzymatic activity is crucial for the removal of ubiquitin from ubiquitinated proteins, a process essential for protein degradation and signaling.
Therapeutic significance:
Understanding the role of Ubiquitin carboxyl-terminal hydrolase 42 could open doors to potential therapeutic strategies. Its unique function in spermatogenesis highlights its importance in reproductive biology and offers a promising avenue for the development of treatments targeting reproductive health issues.