Explore the Potential with AI-Driven Innovation
The focused library is created on demand with the latest virtual screening and parameter assessment technology, supported by the Receptor.AI drug discovery platform. This method is more effective than traditional methods and results in higher-quality compounds with better activity, selectivity, and safety.
We pick out particular compounds from an extensive virtual database of more than 60 billion molecules. The preparation and shipment of these compounds are facilitated by our associate Reaxense.
In the library, a selection of top modulators is provided, each marked with 38 ADME-Tox and 32 parameters related to physicochemical properties and drug-likeness. Also, every compound comes with its best docking poses, affinity scores, and activity scores, providing a comprehensive overview.
We use our state-of-the-art dedicated workflow for designing focused libraries.
Fig. 1. The sreening workflow of Receptor.AI
Our methodology employs molecular simulations to explore a wide array of proteins, capturing their dynamic states both individually and within complexes. Through ensemble virtual screening, we address conformational mobility, uncovering binding sites within functional regions and remote allosteric locations. This thorough exploration ensures no potential mechanism of action is overlooked, aiming to discover novel therapeutic targets and lead compounds across an extensive spectrum of biological functions.
Our library stands out due to several important features:
partner
Reaxense
upacc
Q9H9S4
UPID:
CB39L_HUMAN
Alternative names:
Antigen MLAA-34; MO25beta; Mo25-like protein
Alternative UPACC:
Q9H9S4; Q5TAW6; Q6WG71; Q96FG1; Q9BZ33
Background:
Calcium-binding protein 39-like, also known as MO25beta or Mo25-like protein, plays a crucial role in cellular processes by being a part of a complex that activates STK11/LKB1. This activation is essential for stabilizing the interaction between CAB39/MO25 and STK11/LKB1, highlighting its significance in cellular signaling pathways.
Therapeutic significance:
Understanding the role of Calcium-binding protein 39-like could open doors to potential therapeutic strategies. Its involvement in the activation of STK11/LKB1 suggests its potential impact on diseases where this pathway is dysregulated.