Explore the Potential with AI-Driven Innovation
This comprehensive focused library is produced on demand with state-of-the-art virtual screening and parameter assessment technology driven by Receptor.AI drug discovery platform. This approach outperforms traditional methods and provides higher-quality compounds with superior activity, selectivity and safety.
The compounds are cherry-picked from the vast virtual chemical space of over 60B molecules. The synthesis and delivery of compounds is facilitated by our partner Reaxense.
The library includes a list of the most promising modulators annotated with 38 ADME-Tox and 32 physicochemical and drug-likeness parameters. Also, each compound is presented with its optimal docking poses, affinity scores, and activity scores, providing a comprehensive overview.
Our top-notch dedicated system is used to design specialised libraries for enzymes.
Fig. 1. The sreening workflow of Receptor.AI
This approach involves comprehensive molecular simulations of the catalytic and allosteric binding pockets and ensemble virtual screening that accounts for their conformational flexibility. In the case of designing modulators, the structural adjustments caused by reaction intermediates are considered to improve activity and selectivity.
Our library distinguishes itself through several key aspects:
partner
Reaxense
upacc
Q9HA47
UPID:
UCK1_HUMAN
Alternative names:
Cytidine monophosphokinase 1; Uridine monophosphokinase 1
Alternative UPACC:
Q9HA47; Q5JT09; Q5JT10; Q5JT12; Q5JT13; Q6IA74; Q96BJ0
Background:
Uridine-cytidine kinase 1, also known as Cytidine monophosphokinase 1 and Uridine monophosphokinase 1, plays a crucial role in nucleotide metabolism by phosphorylating uridine and cytidine to their monophosphate forms. This enzyme exhibits specificity towards ribonucleosides but not deoxyribonucleosides or purine ribonucleosides, and can utilize both ATP and GTP as phosphate donors. Its ability to phosphorylate a range of nucleoside analogs highlights its potential in drug metabolism and design.
Therapeutic significance:
Understanding the role of Uridine-cytidine kinase 1 could open doors to potential therapeutic strategies. Its specificity and activity towards various nucleoside analogs suggest its importance in the development of antiviral and anticancer drugs, offering a promising avenue for targeted drug discovery.