Explore the Potential with AI-Driven Innovation
This extensive focused library is tailor-made using the latest virtual screening and parameter assessment technology, operated by the Receptor.AI drug discovery platform. This technique is more effective than traditional methods, offering compounds with improved activity, selectivity, and safety.
From a virtual chemical space containing more than 60 billion molecules, we precisely choose certain compounds. Our collaborator, Reaxense, aids in their synthesis and provision.
Contained in the library are leading modulators, each labelled with 38 ADME-Tox and 32 physicochemical and drug-likeness qualities. In addition, each compound is illustrated with its optimal docking poses, affinity scores, and activity scores, giving a complete picture.
We employ our advanced, specialised process to create targeted libraries.
Fig. 1. The sreening workflow of Receptor.AI
Our strategy employs molecular simulations to explore an extensive range of proteins, capturing their dynamics both individually and within complexes with other proteins. Through ensemble virtual screening, we address proteins' conformational mobility, uncovering key binding sites at both functional regions and remote allosteric locations. This comprehensive investigation ensures a thorough assessment of all potential mechanisms of action, with the goal of discovering innovative therapeutic targets and lead molecules across across diverse biological functions.
Several key aspects differentiate our library:
partner
Reaxense
upacc
Q9HA72
UPID:
CAHM2_HUMAN
Alternative names:
Protein FAM26B
Alternative UPACC:
Q9HA72; D3DR94; O95893; Q6ZUV9
Background:
Calcium homeostasis modulator protein 2, also known as Protein FAM26B, plays a crucial role as the pore-forming subunit of a voltage-gated ion channel. This protein is pivotal in regulating ion flow across the cell membrane, influencing cellular processes and signaling.
Therapeutic significance:
Understanding the role of Calcium homeostasis modulator protein 2 could open doors to potential therapeutic strategies. Its involvement in ion channel regulation presents a unique opportunity for the development of targeted treatments in diseases where ion channel dysfunction is a key factor.