Explore the Potential with AI-Driven Innovation
This comprehensive focused library is produced on demand with state-of-the-art virtual screening and parameter assessment technology driven by Receptor.AI drug discovery platform. This approach outperforms traditional methods and provides higher-quality compounds with superior activity, selectivity and safety.
We carefully select specific compounds from a vast collection of over 60 billion molecules in virtual chemical space. Our partner Reaxense helps in synthesizing and delivering these compounds.
The library features a range of promising modulators, each detailed with 38 ADME-Tox and 32 physicochemical and drug-likeness parameters. Plus, each compound is presented with its ideal docking poses, affinity scores, and activity scores, ensuring a thorough insight.
Our top-notch dedicated system is used to design specialised libraries.
Fig. 1. The sreening workflow of Receptor.AI
Our methodology leverages molecular simulations to examine a vast array of proteins, capturing their dynamics in both isolated forms and in complexes with other proteins. Through ensemble virtual screening, we thoroughly account for the protein's conformational mobility, identifying critical binding sites within functional regions and distant allosteric locations. This detailed exploration ensures that we comprehensively assess every possible mechanism of action, with the objective of identifying novel therapeutic targets and lead compounds that span a wide spectrum of biological functions.
Our library is unique due to several crucial aspects:
partner
Reaxense
upacc
Q9HBE4
UPID:
IL21_HUMAN
Alternative names:
Za11
Alternative UPACC:
Q9HBE4; A5J0L4
Background:
Interleukin-21 (IL-21), also known by its alternative name Za11, plays a pivotal role in the immune system. It regulates the transition between innate and adaptive immunity, influences B-cell differentiation, and is crucial for the production of specific immunoglobulin types. IL-21's involvement extends to the maturation of natural killer (NK) cells and the proliferation of mature B- and T-cells, highlighting its comprehensive role in immune response modulation.
Therapeutic significance:
Given its central role in immune regulation and its direct link to Immunodeficiency, common variable, 11, IL-21 represents a promising target for therapeutic intervention. Understanding the role of Interleukin-21 could open doors to potential therapeutic strategies, particularly in enhancing immune response and correcting immunodeficiency disorders.