Explore the Potential with AI-Driven Innovation
This extensive focused library is tailor-made using the latest virtual screening and parameter assessment technology, operated by the Receptor.AI drug discovery platform. This technique is more effective than traditional methods, offering compounds with improved activity, selectivity, and safety.
The compounds are cherry-picked from the vast virtual chemical space of over 60B molecules. The synthesis and delivery of compounds is facilitated by our partner Reaxense.
In the library, a selection of top modulators is provided, each marked with 38 ADME-Tox and 32 parameters related to physicochemical properties and drug-likeness. Also, every compound comes with its best docking poses, affinity scores, and activity scores, providing a comprehensive overview.
We employ our advanced, specialised process to create targeted libraries.
Fig. 1. The sreening workflow of Receptor.AI
Our methodology leverages molecular simulations to examine a vast array of proteins, capturing their dynamics in both isolated forms and in complexes with other proteins. Through ensemble virtual screening, we thoroughly account for the protein's conformational mobility, identifying critical binding sites within functional regions and distant allosteric locations. This detailed exploration ensures that we comprehensively assess every possible mechanism of action, with the objective of identifying novel therapeutic targets and lead compounds that span a wide spectrum of biological functions.
Our library stands out due to several important features:
partner
Reaxense
upacc
Q9HBG6
UPID:
IF122_HUMAN
Alternative names:
WD repeat-containing protein 10; WD repeat-containing protein 140
Alternative UPACC:
Q9HBG6; B3KW53; B4DEY9; B4DPW7; E7EQF4; E9PDG2; E9PDX2; G3XAB1; H7C3C0; Q53G36; Q8TC06; Q9BTB9; Q9BTY4; Q9HAT9; Q9HBG5; Q9NV68; Q9UF80
Background:
Intraflagellar transport protein 122 homolog, also known as WD repeat-containing protein 10 or 140, plays a crucial role in ciliogenesis and ciliary protein trafficking. It is a part of the IFT complex A, essential for retrograde ciliary transport and GPCR entry into cilia. This protein is pivotal in neuronal patterning and acts as a negative regulator of Shh signaling, highlighting its multifaceted role in cellular functions.
Therapeutic significance:
Cranioectodermal dysplasia 1, a disorder marked by craniofacial, skeletal, and ectodermal abnormalities, is linked to variants affecting this gene. Understanding the role of Intraflagellar transport protein 122 homolog could open doors to potential therapeutic strategies for this condition.