Explore the Potential with AI-Driven Innovation
Our detailed focused library is generated on demand with advanced virtual screening and parameter assessment technology powered by the Receptor.AI drug discovery platform. This method surpasses traditional approaches, delivering compounds of better quality with enhanced activity, selectivity, and safety.
We carefully select specific compounds from a vast collection of over 60 billion molecules in virtual chemical space. Our partner Reaxense helps in synthesizing and delivering these compounds.
In the library, a selection of top modulators is provided, each marked with 38 ADME-Tox and 32 parameters related to physicochemical properties and drug-likeness. Also, every compound comes with its best docking poses, affinity scores, and activity scores, providing a comprehensive overview.
We use our state-of-the-art dedicated workflow for designing focused libraries for enzymes.
Fig. 1. The sreening workflow of Receptor.AI
It includes comprehensive molecular simulations of the catalytic and allosteric binding pockets and the ensemble virtual screening accounting for their conformational mobility. In the case of designing modulators, the structural changes induced by reaction intermediates are taken into account to leverage activity and selectivity.
Our library distinguishes itself through several key aspects:
partner
Reaxense
upacc
Q9HCE1
UPID:
MOV10_HUMAN
Alternative names:
Armitage homolog; Moloney leukemia virus 10 protein
Alternative UPACC:
Q9HCE1; Q5JR03; Q8TEF0; Q9BSY3; Q9BUJ9
Background:
Helicase MOV-10, also known as Armitage homolog and Moloney leukemia virus 10 protein, plays a pivotal role in cellular processes including mRNA metabolism, translation, and synaptic transmission. It is crucial for innate antiviral immunity, promoting type I interferon production and blocking HIV-1 replication. MOV-10 is involved in microRNA-mediated gene silencing and is essential for embryonic viability and central nervous system development.
Therapeutic significance:
Understanding the role of Helicase MOV-10 could open doors to potential therapeutic strategies. Its involvement in antiviral immunity and regulation of viral infectivity highlights its potential as a target in antiviral drug discovery. Additionally, its role in central nervous system development suggests its therapeutic relevance in neurological disorders.