Explore the Potential with AI-Driven Innovation
Our detailed focused library is generated on demand with advanced virtual screening and parameter assessment technology powered by the Receptor.AI drug discovery platform. This method surpasses traditional approaches, delivering compounds of better quality with enhanced activity, selectivity, and safety.
We pick out particular compounds from an extensive virtual database of more than 60 billion molecules. The preparation and shipment of these compounds are facilitated by our associate Reaxense.
In the library, a selection of top modulators is provided, each marked with 38 ADME-Tox and 32 parameters related to physicochemical properties and drug-likeness. Also, every compound comes with its best docking poses, affinity scores, and activity scores, providing a comprehensive overview.
We use our state-of-the-art dedicated workflow for designing focused libraries.
Fig. 1. The sreening workflow of Receptor.AI
Utilising molecular simulations, our approach thoroughly examines a wide array of proteins, tracking their conformational changes individually and within complexes. Ensemble virtual screening enables us to address conformational flexibility, revealing essential binding sites at functional regions and allosteric locations. Our rigorous analysis guarantees that no potential mechanism of action is overlooked, aiming to uncover new therapeutic targets and lead compounds across diverse biological functions.
Our library stands out due to several important features:
partner
Reaxense
upacc
Q9HCE5
UPID:
MET14_HUMAN
Alternative names:
Methyltransferase-like protein 14
Alternative UPACC:
Q9HCE5; A6NIG1; Q969V2
Background:
Methyltransferase-like protein 14, part of the METTL3-METTL14 heterodimer, plays a crucial role in the methylation of adenosine residues in mRNA. This process is vital for the regulation of the circadian clock, embryonic stem cell differentiation, and cortical neurogenesis. METTL14 primarily acts as the RNA-binding scaffold, recognizing substrates for methylation, a key step in mRNA stability and processing.
Therapeutic significance:
Understanding the role of Methyltransferase-like protein 14 could open doors to potential therapeutic strategies. Its involvement in fundamental biological processes such as stem cell differentiation and neurogenesis highlights its potential as a target in regenerative medicine and neurological disorders.