Explore the Potential with AI-Driven Innovation
The focused library is created on demand with the latest virtual screening and parameter assessment technology, supported by the Receptor.AI drug discovery platform. This method is more effective than traditional methods and results in higher-quality compounds with better activity, selectivity, and safety.
Our selection of compounds is from a large virtual library of over 60 billion molecules. The production and distribution of these compounds are managed by our partner Reaxense.
Contained in the library are leading modulators, each labelled with 38 ADME-Tox and 32 physicochemical and drug-likeness qualities. In addition, each compound is illustrated with its optimal docking poses, affinity scores, and activity scores, giving a complete picture.
We utilise our cutting-edge, exclusive workflow to develop focused libraries.
Fig. 1. The sreening workflow of Receptor.AI
Our methodology leverages molecular simulations to examine a vast array of proteins, capturing their dynamics in both isolated forms and in complexes with other proteins. Through ensemble virtual screening, we thoroughly account for the protein's conformational mobility, identifying critical binding sites within functional regions and distant allosteric locations. This detailed exploration ensures that we comprehensively assess every possible mechanism of action, with the objective of identifying novel therapeutic targets and lead compounds that span a wide spectrum of biological functions.
Our library distinguishes itself through several key aspects:
partner
Reaxense
upacc
Q9HCU5
UPID:
PREB_HUMAN
Alternative names:
Mammalian guanine nucleotide exchange factor mSec12
Alternative UPACC:
Q9HCU5; Q53SZ8; Q9UH94
Background:
Prolactin regulatory element-binding protein, also known as Mammalian guanine nucleotide exchange factor mSec12, plays a pivotal role in cellular processes. It activates the small GTPase SAR1B, essential for COPII transport vesicle formation from the ER, and regulates pituitary gene transcription by binding to the prolactin gene promoter.
Therapeutic significance:
Understanding the role of Prolactin regulatory element-binding protein could open doors to potential therapeutic strategies.