Explore the Potential with AI-Driven Innovation
This extensive focused library is tailor-made using the latest virtual screening and parameter assessment technology, operated by the Receptor.AI drug discovery platform. This technique is more effective than traditional methods, offering compounds with improved activity, selectivity, and safety.
The compounds are cherry-picked from the vast virtual chemical space of over 60B molecules. The synthesis and delivery of compounds is facilitated by our partner Reaxense.
In the library, a selection of top modulators is provided, each marked with 38 ADME-Tox and 32 parameters related to physicochemical properties and drug-likeness. Also, every compound comes with its best docking poses, affinity scores, and activity scores, providing a comprehensive overview.
We utilise our cutting-edge, exclusive workflow to develop focused libraries.
Fig. 1. The sreening workflow of Receptor.AI
By deploying molecular simulations, our approach comprehensively covers a broad array of proteins, tracking their flexibility and dynamics individually and within complexes. Ensemble virtual screening is utilised to take into account conformational dynamics, identifying pivotal binding sites located within functional regions and at allosteric locations. This thorough exploration ensures that every conceivable mechanism of action is considered, aiming to identify new therapeutic targets and advance lead compounds throughout a vast spectrum of biological functions.
Key features that set our library apart include:
partner
Reaxense
upacc
Q9NP62
UPID:
GCM1_HUMAN
Alternative names:
GCM motif protein 1; Glial cells missing homolog 1
Alternative UPACC:
Q9NP62; Q4VAQ7; Q5T0X0; Q99468; Q9P1X3
Background:
Chorion-specific transcription factor GCMa, also known as GCM motif protein 1 or Glial cells missing homolog 1, plays a pivotal role in placental development. It regulates the expression of placental growth factor and other placenta-specific genes, binding to specific elements of gene enhancers. Its involvement in the differentiation of trophoblast cells highlights its central role in both villous and extravillous pathways, essential for the development of the placenta.
Therapeutic significance:
Understanding the role of Chorion-specific transcription factor GCMa could open doors to potential therapeutic strategies.