Explore the Potential with AI-Driven Innovation
This comprehensive focused library is produced on demand with state-of-the-art virtual screening and parameter assessment technology driven by Receptor.AI drug discovery platform. This approach outperforms traditional methods and provides higher-quality compounds with superior activity, selectivity and safety.
From a virtual chemical space containing more than 60 billion molecules, we precisely choose certain compounds. Our collaborator, Reaxense, aids in their synthesis and provision.
In the library, a selection of top modulators is provided, each marked with 38 ADME-Tox and 32 parameters related to physicochemical properties and drug-likeness. Also, every compound comes with its best docking poses, affinity scores, and activity scores, providing a comprehensive overview.
We utilise our cutting-edge, exclusive workflow to develop focused libraries.
Fig. 1. The sreening workflow of Receptor.AI
Our methodology employs molecular simulations to explore a wide array of proteins, capturing their dynamic states both individually and within complexes. Through ensemble virtual screening, we address conformational mobility, uncovering binding sites within functional regions and remote allosteric locations. This thorough exploration ensures no potential mechanism of action is overlooked, aiming to discover novel therapeutic targets and lead compounds across an extensive spectrum of biological functions.
Key features that set our library apart include:
partner
Reaxense
upacc
Q9NPD3
UPID:
EXOS4_HUMAN
Alternative names:
Exosome component 4; Ribosomal RNA-processing protein 41; p12A
Alternative UPACC:
Q9NPD3
Background:
Exosome complex component RRP41, also known as Exosome component 4 and Ribosomal RNA-processing protein 41, plays a crucial role in RNA metabolism. It is a non-catalytic component of the RNA exosome complex, involved in the degradation and processing of various RNA species. This includes the maturation of stable RNA species, elimination of RNA processing by-products, and degradation of unstable mRNAs. Its activity is essential in both the nucleus and the cytoplasm for maintaining RNA homeostasis.
Therapeutic significance:
Understanding the role of Exosome complex component RRP41 could open doors to potential therapeutic strategies.