Explore the Potential with AI-Driven Innovation
This extensive focused library is tailor-made using the latest virtual screening and parameter assessment technology, operated by the Receptor.AI drug discovery platform. This technique is more effective than traditional methods, offering compounds with improved activity, selectivity, and safety.
Our selection of compounds is from a large virtual library of over 60 billion molecules. The production and distribution of these compounds are managed by our partner Reaxense.
Contained in the library are leading modulators, each labelled with 38 ADME-Tox and 32 physicochemical and drug-likeness qualities. In addition, each compound is illustrated with its optimal docking poses, affinity scores, and activity scores, giving a complete picture.
We employ our advanced, specialised process to create targeted libraries.
Fig. 1. The sreening workflow of Receptor.AI
By deploying molecular simulations, our approach comprehensively covers a broad array of proteins, tracking their flexibility and dynamics individually and within complexes. Ensemble virtual screening is utilised to take into account conformational dynamics, identifying pivotal binding sites located within functional regions and at allosteric locations. This thorough exploration ensures that every conceivable mechanism of action is considered, aiming to identify new therapeutic targets and advance lead compounds throughout a vast spectrum of biological functions.
Key features that set our library apart include:
partner
Reaxense
upacc
Q9NQA5
UPID:
TRPV5_HUMAN
Alternative names:
Calcium transport protein 2; Epithelial calcium channel 1; Osm-9-like TRP channel 3
Alternative UPACC:
Q9NQA5; A4D2H7; E9PBZ6; Q8N4C1; Q8NDW5; Q8NDX7; Q8NDX8; Q96PM6
Background:
Transient receptor potential cation channel subfamily V member 5 (TRPV5), also known as Calcium transport protein 2, plays a pivotal role in calcium homeostasis by facilitating calcium reabsorption in kidney and intestine. It operates as a constitutively active calcium-selective channel, which is crucial for maintaining normal calcium levels in the body. The channel's activity is modulated by internal calcium levels, exhibiting inward rectification and a Ca(2+)-dependent feedback mechanism for regulation.
Therapeutic significance:
Understanding the role of Transient receptor potential cation channel subfamily V member 5 could open doors to potential therapeutic strategies.