Explore the Potential with AI-Driven Innovation
Our detailed focused library is generated on demand with advanced virtual screening and parameter assessment technology powered by the Receptor.AI drug discovery platform. This method surpasses traditional approaches, delivering compounds of better quality with enhanced activity, selectivity, and safety.
Our selection of compounds is from a large virtual library of over 60 billion molecules. The production and distribution of these compounds are managed by our partner Reaxense.
The library includes a list of the most promising modulators annotated with 38 ADME-Tox and 32 physicochemical and drug-likeness parameters. Also, each compound is presented with its optimal docking poses, affinity scores, and activity scores, providing a comprehensive overview.
We employ our advanced, specialised process to create targeted libraries for enzymes.
Fig. 1. The sreening workflow of Receptor.AI
The procedure entails thorough molecular simulations of the catalytic and allosteric binding pockets, accompanied by ensemble virtual screening that factors in their conformational flexibility. When developing modulators, the structural modifications brought about by reaction intermediates are factored in to optimize activity and selectivity.
Our library distinguishes itself through several key aspects:
partner
Reaxense
upacc
Q9NQE7
UPID:
TSSP_HUMAN
Alternative names:
Serine protease 16
Alternative UPACC:
Q9NQE7; O75416
Background:
The Thymus-specific serine protease, also known as Serine protease 16, plays a crucial role in T-cell development. This protease's unique function within the immune system highlights its importance in maintaining immune homeostasis and ensuring a properly functioning adaptive immune response.
Therapeutic significance:
Understanding the role of Thymus-specific serine protease could open doors to potential therapeutic strategies. Its pivotal role in T-cell development positions it as a key target for modulating immune responses, offering avenues for innovative treatments in immune-related disorders.