Explore the Potential with AI-Driven Innovation
This comprehensive focused library is produced on demand with state-of-the-art virtual screening and parameter assessment technology driven by Receptor.AI drug discovery platform. This approach outperforms traditional methods and provides higher-quality compounds with superior activity, selectivity and safety.
We pick out particular compounds from an extensive virtual database of more than 60 billion molecules. The preparation and shipment of these compounds are facilitated by our associate Reaxense.
The library includes a list of the most promising modulators annotated with 38 ADME-Tox and 32 physicochemical and drug-likeness parameters. Also, each compound is presented with its optimal docking poses, affinity scores, and activity scores, providing a comprehensive overview.
Our top-notch dedicated system is used to design specialised libraries.
Fig. 1. The sreening workflow of Receptor.AI
Our strategy employs molecular simulations to explore an extensive range of proteins, capturing their dynamics both individually and within complexes with other proteins. Through ensemble virtual screening, we address proteins' conformational mobility, uncovering key binding sites at both functional regions and remote allosteric locations. This comprehensive investigation ensures a thorough assessment of all potential mechanisms of action, with the goal of discovering innovative therapeutic targets and lead molecules across across diverse biological functions.
Our library stands out due to several important features:
partner
Reaxense
upacc
Q9NQG6
UPID:
MID51_HUMAN
Alternative names:
Mitochondrial dynamics protein of 51 kDa; Mitochondrial elongation factor 1; Smith-Magenis syndrome chromosomal region candidate gene 7 protein-like
Alternative UPACC:
Q9NQG6; Q7L890; Q9BUI3
Background:
Mitochondrial dynamics protein MIEF1, also known as Mitochondrial dynamics protein of 51 kDa, Mitochondrial elongation factor 1, and Smith-Magenis syndrome chromosomal region candidate gene 7 protein-like, plays a crucial role in mitochondrial fission. It facilitates the recruitment of dynamin-related protein 1 (DNM1L) to the mitochondrial surface, enhancing DNM1L's GTPase activity and oligomerization. MIEF1's unique ability to bind ADP and influence DNM1L's assembly into tubules underscores its significance in mitochondrial dynamics.
Therapeutic significance:
Understanding the role of Mitochondrial dynamics protein MIEF1 could open doors to potential therapeutic strategies.