Explore the Potential with AI-Driven Innovation
This comprehensive focused library is produced on demand with state-of-the-art virtual screening and parameter assessment technology driven by Receptor.AI drug discovery platform. This approach outperforms traditional methods and provides higher-quality compounds with superior activity, selectivity and safety.
The compounds are cherry-picked from the vast virtual chemical space of over 60B molecules. The synthesis and delivery of compounds is facilitated by our partner Reaxense.
The library includes a list of the most effective modulators, each annotated with 38 ADME-Tox and 32 physicochemical and drug-likeness parameters. Furthermore, each compound is shown with its optimal docking poses, affinity scores, and activity scores, offering a detailed summary.
We utilise our cutting-edge, exclusive workflow to develop focused libraries.
Fig. 1. The sreening workflow of Receptor.AI
Our methodology leverages molecular simulations to examine a vast array of proteins, capturing their dynamics in both isolated forms and in complexes with other proteins. Through ensemble virtual screening, we thoroughly account for the protein's conformational mobility, identifying critical binding sites within functional regions and distant allosteric locations. This detailed exploration ensures that we comprehensively assess every possible mechanism of action, with the objective of identifying novel therapeutic targets and lead compounds that span a wide spectrum of biological functions.
Our library stands out due to several important features:
partner
Reaxense
upacc
Q9NQZ6
UPID:
ZC4H2_HUMAN
Alternative names:
Hepatocellular carcinoma-associated antigen 127
Alternative UPACC:
Q9NQZ6; B2RDC2; B3KVZ5; B4DED0; E7EM74; G3V1L3; Q53H73; Q5JTF9; Q9H9C3; Q9H9H7; Q9ULQ4
Background:
The Zinc finger C4H2 domain-containing protein, also known as Hepatocellular carcinoma-associated antigen 127, plays a pivotal role in the differentiation of interneurons and is crucial for neuronal development and neuromuscular junction formation. Its involvement in these fundamental processes underscores its importance in the central and peripheral nervous systems.
Therapeutic significance:
Linked to severe neurodevelopmental disorders such as Wieacker-Wolf syndrome and its female-restricted variant, understanding the role of this protein could open doors to potential therapeutic strategies. These conditions, characterized by muscle weakness, contractures, and developmental delays, highlight the protein's critical role in neuromuscular development.