Explore the Potential with AI-Driven Innovation
This extensive focused library is tailor-made using the latest virtual screening and parameter assessment technology, operated by the Receptor.AI drug discovery platform. This technique is more effective than traditional methods, offering compounds with improved activity, selectivity, and safety.
Our selection of compounds is from a large virtual library of over 60 billion molecules. The production and distribution of these compounds are managed by our partner Reaxense.
In the library, a selection of top modulators is provided, each marked with 38 ADME-Tox and 32 parameters related to physicochemical properties and drug-likeness. Also, every compound comes with its best docking poses, affinity scores, and activity scores, providing a comprehensive overview.
Our high-tech, dedicated method is applied to construct targeted libraries for enzymes.
Fig. 1. The sreening workflow of Receptor.AI
It includes in-depth molecular simulations of both the catalytic and allosteric binding pockets, with ensemble virtual screening focusing on their conformational flexibility. For modulators, the process includes considering the structural shifts due to reaction intermediates to boost activity and selectivity.
Our library distinguishes itself through several key aspects:
partner
Reaxense
upacc
Q9NR22
UPID:
ANM8_HUMAN
Alternative names:
Heterogeneous nuclear ribonucleoprotein methyltransferase-like protein 4
Alternative UPACC:
Q9NR22; B2RDP0; Q8TBJ8
Background:
Protein arginine N-methyltransferase 8 (PRMT8), also known as Heterogeneous nuclear ribonucleoprotein methyltransferase-like protein 4, is a key enzyme in the post-translational modification of proteins. It specializes in the methylation of arginine residues, a process critical for the modulation of protein function and signaling. PRMT8's activity includes the formation of omega-N monomethylarginine (MMA) and asymmetrical dimethylarginine (aDMA), impacting proteins such as NIFK, myelin basic protein, and histones H4, H2A, and the H2A/H2B dimer.
Therapeutic significance:
Understanding the role of Protein arginine N-methyltransferase 8 could open doors to potential therapeutic strategies.