Explore the Potential with AI-Driven Innovation
The focused library is created on demand with the latest virtual screening and parameter assessment technology, supported by the Receptor.AI drug discovery platform. This method is more effective than traditional methods and results in higher-quality compounds with better activity, selectivity, and safety.
The compounds are cherry-picked from the vast virtual chemical space of over 60B molecules. The synthesis and delivery of compounds is facilitated by our partner Reaxense.
The library includes a list of the most effective modulators, each annotated with 38 ADME-Tox and 32 physicochemical and drug-likeness parameters. Furthermore, each compound is shown with its optimal docking poses, affinity scores, and activity scores, offering a detailed summary.
Our high-tech, dedicated method is applied to construct targeted libraries for enzymes.
Fig. 1. The sreening workflow of Receptor.AI
It includes comprehensive molecular simulations of the catalytic and allosteric binding pockets and the ensemble virtual screening accounting for their conformational mobility. In the case of designing modulators, the structural changes induced by reaction intermediates are taken into account to leverage activity and selectivity.
Our library stands out due to several important features:
partner
Reaxense
upacc
Q9NR30
UPID:
DDX21_HUMAN
Alternative names:
DEAD box protein 21; Gu-alpha; Nucleolar RNA helicase Gu; Nucleolar RNA helicase II; RH II/Gu
Alternative UPACC:
Q9NR30; B2RDL0; Q13436; Q5VX41; Q68D35
Background:
Nucleolar RNA helicase 2, also known as DEAD box protein 21 and several other names, plays a pivotal role in RNA metabolism. It acts as a sensor for the transcriptional status of RNA polymerases I and II, facilitating rRNA processing, transcription, and modification. This protein binds various RNAs, promoting rRNA 2'-O-methylation and transcription of Pol II-transcribed genes. Its helicase activity is crucial for unwinding double-stranded RNA and introducing secondary structures to single-stranded RNA.
Therapeutic significance:
Understanding the role of Nucleolar RNA helicase 2 could open doors to potential therapeutic strategies.