Explore the Potential with AI-Driven Innovation
This extensive focused library is tailor-made using the latest virtual screening and parameter assessment technology, operated by the Receptor.AI drug discovery platform. This technique is more effective than traditional methods, offering compounds with improved activity, selectivity, and safety.
We carefully select specific compounds from a vast collection of over 60 billion molecules in virtual chemical space. Our partner Reaxense helps in synthesizing and delivering these compounds.
The library includes a list of the most promising modulators annotated with 38 ADME-Tox and 32 physicochemical and drug-likeness parameters. Also, each compound is presented with its optimal docking poses, affinity scores, and activity scores, providing a comprehensive overview.
Our high-tech, dedicated method is applied to construct targeted libraries.
Fig. 1. The sreening workflow of Receptor.AI
Utilising molecular simulations, our approach thoroughly examines a wide array of proteins, tracking their conformational changes individually and within complexes. Ensemble virtual screening enables us to address conformational flexibility, revealing essential binding sites at functional regions and allosteric locations. Our rigorous analysis guarantees that no potential mechanism of action is overlooked, aiming to uncover new therapeutic targets and lead compounds across diverse biological functions.
Key features that set our library apart include:
partner
Reaxense
upacc
Q9NRH3
UPID:
TBG2_HUMAN
Alternative names:
Gamma-2-tubulin
Alternative UPACC:
Q9NRH3; A6NDI4; Q32NB2
Background:
Tubulin gamma-2 chain, also known as Gamma-2-tubulin, plays a pivotal role in cell division by constituting microtubules. It is specifically located at microtubule organizing centers (MTOC), including spindle poles and the centrosome. This protein is essential for the nucleation of alpha/beta chain minus-end, centrosome duplication, and spindle formation, facilitating accurate chromosome segregation during cell division.
Therapeutic significance:
Understanding the role of Tubulin gamma-2 chain could open doors to potential therapeutic strategies. Its critical function in cell division makes it a potential target for cancer therapy, where regulation of cell proliferation is a key treatment objective.