Explore the Potential with AI-Driven Innovation
The focused library is created on demand with the latest virtual screening and parameter assessment technology, supported by the Receptor.AI drug discovery platform. This method is more effective than traditional methods and results in higher-quality compounds with better activity, selectivity, and safety.
We carefully select specific compounds from a vast collection of over 60 billion molecules in virtual chemical space. Our partner Reaxense helps in synthesizing and delivering these compounds.
Contained in the library are leading modulators, each labelled with 38 ADME-Tox and 32 physicochemical and drug-likeness qualities. In addition, each compound is illustrated with its optimal docking poses, affinity scores, and activity scores, giving a complete picture.
Our top-notch dedicated system is used to design specialised libraries.
Fig. 1. The sreening workflow of Receptor.AI
Our methodology employs molecular simulations to explore a wide array of proteins, capturing their dynamic states both individually and within complexes. Through ensemble virtual screening, we address conformational mobility, uncovering binding sites within functional regions and remote allosteric locations. This thorough exploration ensures no potential mechanism of action is overlooked, aiming to discover novel therapeutic targets and lead compounds across an extensive spectrum of biological functions.
Our library is unique due to several crucial aspects:
partner
Reaxense
upacc
Q9NRJ3
UPID:
CCL28_HUMAN
Alternative names:
Mucosae-associated epithelial chemokine; Protein CCK1; Small-inducible cytokine A28
Alternative UPACC:
Q9NRJ3; D7RIE7
Background:
C-C motif chemokine 28, also known as Mucosae-associated epithelial chemokine, Protein CCK1, and Small-inducible cytokine A28, plays a pivotal role in immune responses. It exhibits chemotactic activity for resting CD4, CD8 T-cells, and eosinophils by binding to CCR3 and CCR10, inducing calcium mobilization in a dose-dependent manner.
Therapeutic significance:
Understanding the role of C-C motif chemokine 28 could open doors to potential therapeutic strategies, particularly in modulating immune responses and treating inflammatory conditions.