Explore the Potential with AI-Driven Innovation
The focused library is created on demand with the latest virtual screening and parameter assessment technology, supported by the Receptor.AI drug discovery platform. This method is more effective than traditional methods and results in higher-quality compounds with better activity, selectivity, and safety.
Our selection of compounds is from a large virtual library of over 60 billion molecules. The production and distribution of these compounds are managed by our partner Reaxense.
In the library, a selection of top modulators is provided, each marked with 38 ADME-Tox and 32 parameters related to physicochemical properties and drug-likeness. Also, every compound comes with its best docking poses, affinity scores, and activity scores, providing a comprehensive overview.
We utilise our cutting-edge, exclusive workflow to develop focused libraries for enzymes.
Fig. 1. The sreening workflow of Receptor.AI
It includes comprehensive molecular simulations of the catalytic and allosteric binding pockets and the ensemble virtual screening accounting for their conformational mobility. In the case of designing modulators, the structural changes induced by reaction intermediates are taken into account to leverage activity and selectivity.
Several key aspects differentiate our library:
partner
Reaxense
upacc
Q9NRJ5
UPID:
PAPOB_HUMAN
Alternative names:
Polynucleotide adenylyltransferase beta; Testis-specific poly(A) polymerase
Alternative UPACC:
Q9NRJ5; Q75LH1; Q8NE14
Background:
Poly(A) polymerase beta, also known as Polynucleotide adenylyltransferase beta and Testis-specific poly(A) polymerase, plays a crucial role in the post-transcriptional modification of RNA. Its primary function involves the addition of poly(A) tails to RNA molecules, a process essential for RNA stability and translation efficiency. The protein's unique activity in testis suggests a specialized role in spermatogenesis.
Therapeutic significance:
Understanding the role of Poly(A) polymerase beta could open doors to potential therapeutic strategies. Its involvement in RNA processing and stability positions it as a key player in gene expression regulation, offering a promising target for interventions in diseases where these processes are disrupted.