Explore the Potential with AI-Driven Innovation
This extensive focused library is tailor-made using the latest virtual screening and parameter assessment technology, operated by the Receptor.AI drug discovery platform. This technique is more effective than traditional methods, offering compounds with improved activity, selectivity, and safety.
Our selection of compounds is from a large virtual library of over 60 billion molecules. The production and distribution of these compounds are managed by our partner Reaxense.
The library includes a list of the most effective modulators, each annotated with 38 ADME-Tox and 32 physicochemical and drug-likeness parameters. Furthermore, each compound is shown with its optimal docking poses, affinity scores, and activity scores, offering a detailed summary.
Our top-notch dedicated system is used to design specialised libraries for enzymes.
Fig. 1. The sreening workflow of Receptor.AI
The procedure entails thorough molecular simulations of the catalytic and allosteric binding pockets, accompanied by ensemble virtual screening that factors in their conformational flexibility. When developing modulators, the structural modifications brought about by reaction intermediates are factored in to optimize activity and selectivity.
Our library is unique due to several crucial aspects:
partner
Reaxense
upacc
Q9NRR2
UPID:
TRYG1_HUMAN
Alternative names:
Serine protease 31; Transmembrane tryptase
Alternative UPACC:
Q9NRR2; Q96RZ8; Q9C015; Q9NRQ8; Q9UBB2
Background:
Tryptase gamma, also known as Serine protease 31 and Transmembrane tryptase, is a protein encoded by the gene with the UniProt accession number Q9NRR2. It belongs to a family of tryptases, which are serine proteases involved in various biological processes, including inflammation and immune response. Tryptase gamma's specific functions and mechanisms of action are subjects of ongoing research, highlighting its potential significance in physiological and pathological conditions.
Therapeutic significance:
Understanding the role of Tryptase gamma could open doors to potential therapeutic strategies. Its involvement in key biological processes suggests that modulating its activity could offer new avenues for treating diseases where inflammation and immune response are dysregulated. The exploration of Tryptase gamma's function is crucial for the development of innovative therapeutic approaches.