Explore the Potential with AI-Driven Innovation
The specialised, focused library is developed on demand with the most recent virtual screening and parameter assessment technology, guided by the Receptor.AI drug discovery platform. This approach exceeds the capabilities of traditional methods and offers compounds with higher activity, selectivity, and safety.
Our selection of compounds is from a large virtual library of over 60 billion molecules. The production and distribution of these compounds are managed by our partner Reaxense.
The library features a range of promising modulators, each detailed with 38 ADME-Tox and 32 physicochemical and drug-likeness parameters. Plus, each compound is presented with its ideal docking poses, affinity scores, and activity scores, ensuring a thorough insight.
Our high-tech, dedicated method is applied to construct targeted libraries.
Fig. 1. The sreening workflow of Receptor.AI
Our methodology employs molecular simulations to explore a wide array of proteins, capturing their dynamic states both individually and within complexes. Through ensemble virtual screening, we address conformational mobility, uncovering binding sites within functional regions and remote allosteric locations. This thorough exploration ensures no potential mechanism of action is overlooked, aiming to discover novel therapeutic targets and lead compounds across an extensive spectrum of biological functions.
Our library is unique due to several crucial aspects:
partner
Reaxense
upacc
Q9NRS6
UPID:
SNX15_HUMAN
Alternative names:
-
Alternative UPACC:
Q9NRS6; E5KQS6; Q9NRS5
Background:
Sorting nexin-15 (SNX15) plays a crucial role in intracellular trafficking, influencing the movement of proteins between the plasma membrane, recycling endosomes, and the trans-Golgi network (TGN). Its involvement in these key cellular processes underscores its importance in maintaining cellular function and homeostasis.
Therapeutic significance:
Understanding the role of Sorting nexin-15 could open doors to potential therapeutic strategies. Its pivotal role in intracellular trafficking suggests that modulation of SNX15 activity could influence cellular processes fundamental to disease pathology.